Tapentadol 100 mg is a prescription opioid analgesic used for the management of pain severe enough to require an opioid when alternative treatments are inadequate. Tapentadol acts through opioid receptor activity and norepinephrine reuptake inhibition. It carries important risks including misuse, abuse, addiction, respiratory depression, overdose, and potentially fatal interactions with other medicines. Use only under the direction of a qualified healthcare professional. Current labeling lists 100 mg tablets among the available strengths.